About   Help   FAQ
Tcf7l2em1Nobr
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Tcf7l2em1Nobr
Name: transcription factor 7 like 2, T cell specific, HMG box; endonuclease-mediated mutation 1, Marcelo A Nobrega
MGI ID: MGI:5292672
Synonyms: Line 1
Gene: Tcf7l2  Location: Chr19:55741820-55933654 bp, + strand  Genetic Position: Chr19, 51.59 cM
Mutation
origin
Strain of Origin:  CD-1
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA zinc finger targeting exon 11 (using alternative exon 4 in exon numbering) induced a 1 bp deletion that results in alteration of the amino acids after codon 390 (TLAGLHGITMGRRRREKETSSRGKPTNTANVS) and introduction of a premature stop codon. (J:175874)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  38 strains or lines available
References
Original:  J:175874 Savic D, et al., Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 2011 Sep;21(9):1417-25
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/06/2019
MGI 6.14
The Jackson Laboratory