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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1Lrsn
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Nils-Goran Larsson
MGI ID: MGI:5292496
Synonyms: Gt(ROSA26)SorStop-mito-YFP, ROSA26lox-Stop-lox-mito-YFP, ROSA26SmY
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:176022
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA construct containing a floxed neo stop cassette and a mitochondrial targeted YFP was inserted into the locus. (J:176022)
Design of lox-Stop-lox-mito-YFP and targeting to the ROSA26 locus to generate the Gt(ROSA)26Sortm1Lrsn and Gt(ROSA)26Sortm1.1Lrsn alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  408 strains or lines available
Original:  J:176022 Sterky FH, et al., Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12937-42
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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