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Drd2tm1.1Mrub
Targeted Allele Detail
Nomenclature
Symbol: Drd2tm1.1Mrub
Name: dopamine receptor D2; targeted mutation 1.1, Marcelo Rubinstein
MGI ID: MGI:5292350
Synonyms: Drd2loxP
Gene: Drd2  Location: Chr9:49340627-49408177 bp, + strand  Genetic Position: Chr9, 26.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176167
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 2. (J:176167)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  58 strains or lines available
References
Original:  J:176167 Bello EP, et al., Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat Neurosci. 2011 Aug;14(8):1033-8
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory