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Tnfaip3tm1.1Awai
Targeted Allele Detail
Nomenclature
Symbol: Tnfaip3tm1.1Awai
Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1.1, Ari Waisman
MGI ID: MGI:5291646
Synonyms: A20fl
Gene: Tnfaip3  Location: Chr10:19000910-19015410 bp, - strand  Genetic Position: Chr10, 8.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175422
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exon 3 floxed. (J:175422)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfaip3 Mutation:  28 strains or lines available
References
Original:  J:175422 Hovelmeyer N, et al., A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol. 2011 Mar;41(3):595-601
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory