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Mapk14tm3.1(Mapk11)Nbr
Targeted Allele Detail
Nomenclature
Symbol: Mapk14tm3.1(Mapk11)Nbr
Name: mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda
MGI ID: MGI:5288509
Synonyms: p38alphabetaKI
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Growth retardation and placenta abnormalities in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176023
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cDNA for Mapk11 and a floxed neo cassette were inserted in frame after the ATG codon in exon 1 replacing the rest of exon 1 and part of intron 1. Cre mediated recombination removed the neo cassette. RT-PCR analysis confirmed the expression in all tissues examined (brain, liver, spleen, colon, heart, muscle, kidney, and liver). (J:176023)
Generation of the Mapk14tm3.1(Mapk11)Nbr allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
References
Original:  J:176023 del Barco Barrantes I, et al., Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory