Mapk14^{tm3.1(Mapk11)Nbr}
Targeted Allele Detail

Summary

• Symbol: Mapk14^{tm3.1(Mapk11)Nbr}
• Name: mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda
• MGI ID: MGI:5288509
• Synonyms: p38alpha^betaKI
• Gene: Mapk14 Location: Chr17:28910303-28967380 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^{tm3.1(Mapk11)Nbr} page

Growth retardation and placenta abnormalities in Mapk14^{tm3.1(Mapk11)Nbr}/Mapk14^{tm3.1(Mapk11)Nbr} embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Inserted expressed sequence, Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A cDNA for Mapk11 and a floxed neo cassette were inserted in frame after the ATG codon in exon 1 replacing the rest of exon 1 and part of intron 1. Cre mediated recombination removed the neo cassette. RT-PCR analysis confirmed the expression in all tissues examined (brain, liver, spleen, colon, heart, muscle, kidney, and liver). (J:176023)

Generation of the Mapk14^tm3.1(Mapk11)Nbr allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 41 strains or lines available

References

• Original: J:176023 del Barco Barrantes I, et al., Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9
• All: 1 reference(s)