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Targeted Allele Detail
Symbol: Mapk14tm3.1(Mapk11)Nbr
Name: mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda
MGI ID: MGI:5288509
Synonyms: p38alphabetaKI
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Growth retardation and placenta abnormalities in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:176023
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cDNA for Mapk11 and a floxed neo cassette were inserted in frame after the ATG codon in exon 1 replacing the rest of exon 1 and part of intron 1. Cre mediated recombination removed the neo cassette. RT-PCR analysis confirmed the expression in all tissues examined (brain, liver, spleen, colon, heart, muscle, kidney, and liver). (J:176023)
Generation of the Mapk14tm3.1(Mapk11)Nbr allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
Original:  J:176023 del Barco Barrantes I, et al., Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory