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QTL Variant Detail
QTL variant: Vav3Idd18.1-C57BL/6J
Name: vav 3 oncogene; C57BL/6J
MGI ID: MGI:5288361
Synonyms: Idd18.1C57BL/6
QTL: Vav3  Location: Chr3:109340653-109685698 bp, + strand  Genetic Position: Chr3, 48.13 cM, cytoband G1
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Mutation:    Not Applicable
Mutation detailsNo coding sequence polymorphisms exist between NOD and C57BL/6 mice. However, 138 SNPs are found between intron 20 and the 3' untranslated region. (J:160442)

Candidate Genes


Microarray gene chip technology was used to identify differentially expressed candidate genes for the arthritis QTL on mouse Chromosome 3 named Cia5. The Cia5 QTL microarray chip contains 163 genes found between 95.3 Mb and 109.7 Mb on mouse Chromosome 3. (This region spans markers D3Mit101 to D3Mit103.) Gene expression in lymph nodes, spleen, and paws was compared between the resistant Cia5 congenic and susceptible B10.RIII background strain. Animals were immunized with 100 ug of bovine CII at 12 weeks of age. Gene expression was evaluated at 0, 6, and 12 days after immunization. A total of 26 genes in the Cia5 locus were found to have significant expression differences (P<0.05) between the congenic and B10.RIII. These genes were found in 2 clusters corresponding to Cia21 and Cia22. Some notable candidate genes are described below.

Chi3l3 (50.5 cM; 105.9 Mb) is downregulated in congenic animals in spleen (all time points) and lymph nodes (day 6).

Vav3 (109.1 Mb) is upregulated in congenic animals in spleen (all time points), lymph nodes (day 0), and paws (days 6 and 12).

Gpr89 (96.3 Mb) is upregulated in congenic animals in spleen (all time points) and lymph nodes (day 0).

Ptpn22 (103.2 Mb) is downregulated in congenic animals in lymph nodes (day 0).

Cd53 (50.5 cM; 106.5 Mb) is upregulated in B10.RIII in spleen (day 12) and lymph nodes (day 0).

Gstm1 (107.8 Mb) is upregulated in B10.RIII in spleen and lymph nodes at day 0, but is downregulated after immunization.

Original:  J:160442 Fraser HI, et al., Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol. 2010 May 1;184(9):5075-84
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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