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Dcdc2atm1.2Jjlo
Targeted Allele Detail
Nomenclature
Symbol: Dcdc2atm1.2Jjlo
Name: doublecortin domain containing 2a; targeted mutation 1.2, Joseph J LoTurco
MGI ID: MGI:5288003
Synonyms: Dcdc2del2
Gene: Dcdc2a  Location: Chr13:25056004-25210706 bp, + strand  Genetic Position: Chr13, 10.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175635
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. Quantitative real time PCR showed that expression levels are about 10 fold lower in homozygous mice compared to wild-type mice. (J:175635)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcdc2a Mutation:  18 strains or lines available
References
Original:  J:175635 Wang Y, et al., Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience. 2011 Sep 8;190:398-408
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory