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Nfat5tm1Skc
Targeted Allele Detail
Nomenclature
Symbol: Nfat5tm1Skc
Name: nuclear factor of activated T cells 5; targeted mutation 1, Sookja K Chung
MGI ID: MGI:5287396
Gene: Nfat5  Location: Chr8:107293470-107379517 bp, + strand  Genetic Position: Chr8, 53.93 cM, cytoband D2
Peripheral edema in E14.5 Nfat5tm1Skc/Nfat5tm1Skc embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175527
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsParts of exons 5 and 6 were replaced with a pgk-neo cassette via homologous recombination. RT-PCR confirms the absence of expression in the hearts of homozygous mice at E14.5. (J:175527)
Targeting vector to generate the Nfat5tm1Skc allele
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfat5 Mutation:  34 strains or lines available
References
Original:  J:175527 Mak MC, et al., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function. PLoS One. 2011;6(7):e19186
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory