About   Help   FAQ
Ppp2r1atm3.1Wltr
Targeted Allele Detail
Nomenclature
Symbol: Ppp2r1atm3.1Wltr
Name: protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 3.1, Gernot Walter
MGI ID: MGI:5287370
Synonyms: PP2A-A-alpha-E64G
Gene: Ppp2r1a  Location: Chr17:20945454-20965905 bp, + strand  Genetic Position: Chr17, 11.4 cM, cytoband A3.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175748
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 3 was related with a modified exon 3 in which nucleotide substitutions (GAG to GGC) result in an amino acid substitution of glycine for glutamic acid (E64G), mimicking a mutation found in a human breast carcinoma. A floxed neo cassette inserted downstream of the modified exon 3 was removed by cre-mediated recombination. (J:175748)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp2r1a Mutation:  3 strains or lines available
References
Original:  J:175748 Ruediger R, et al., Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol. 2011 Sep;31(18):3832-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/06/2021
MGI 6.16
The Jackson Laboratory