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Targeted Allele Detail
Symbol: Ppp2r1atm3.1Wltr
Name: protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 3.1, Gernot Walter
MGI ID: MGI:5287370
Synonyms: PP2A-A-alpha-E64G
Gene: Ppp2r1a  Location: Chr17:20945454-20965905 bp, + strand  Genetic Position: Chr17, 11.4 cM, cytoband A3.2
Germline Transmission:  Earliest citation of germline transmission: J:175748
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 3 was related with a modified exon 3 in which nucleotide substitutions (GAG to GGC) result in an amino acid substitution of glycine for glutamic acid (E64G), mimicking a mutation found in a human breast carcinoma. A floxed neo cassette inserted downstream of the modified exon 3 was removed by cre-mediated recombination. (J:175748)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp2r1a Mutation:  3 strains or lines available
Original:  J:175748 Ruediger R, et al., Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol. 2011 Sep;31(18):3832-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory