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Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo
Name: transgene insertion C63, David R Borchelt
MGI ID: MGI:5286114
Synonyms: N586-82Q-C63
Transgene: Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(Prnp-HTT*82Q,KRT14-EGFP)C63Dbo expresses 1 gene
 
Mutation detailsThe mouse promoter drives brain-specific expression of the human cDNA encoding the first 586 N-terminal amino acids (N586) and an expansion of the glutamine tract to 82 (82Q). The transgene was co-integrated with a transgene in which the human promoter drives skin-specific expression fo EGFP. Lines C62 and C63 were generated with the later expressing at higher levels than the former. (J:173756)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:173756 Tebbenkamp AT, et al., Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Hum Mol Genet. 2011 Jul 15;20(14):2770-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory