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Akap12tm1Ihg
Targeted Allele Detail
Nomenclature
Symbol: Akap12tm1Ihg
Name: A kinase (PRKA) anchor protein (gravin) 12; targeted mutation 1, Irwin H Gelman
MGI ID: MGI:5286076
Synonyms: mSSeCKS-
Gene: Akap12  Location: Chr10:4266380-4359470 bp, + strand  Genetic Position: Chr10, 2.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138882
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA lacZ followed by a neomycin selection cassette were inserted in exon2. Western blot analysis demonstrated the absence of all three major isoforms (alpha, beta, gamma). (J:138882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akap12 Mutation:  156 strains or lines available
References
Original:  J:138882 Akakura S, et al., Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia. Cancer Res. 2008 Jul 1;68(13):5096-103
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory