Opn4^{tm2.1(cre/ERT2)Saha}
Targeted Allele Detail

Summary

• Symbol: Opn4^{tm2.1(cre/ERT2)Saha}
• Name: opsin 4 (melanopsin); targeted mutation 2.1, Samer Hattar
• MGI ID: MGI:5285845
• Synonyms: Opn4^CreERT2
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^{tm2.1(cre/ERT2)Saha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174940
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Opn4^{tm2.1(cre/ERT2)Saha} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Opn4 (MGI:1353425)

• Mutation details: The targeting arms and same general strategy used to produce the Opn4^tm1(cre)Saha allele (MGI:4881482) was employed to generate this allele. Differences are that the targeting construct contained the rabbit beta-globin intron, the cre/ERT2 sequence, and an IRES-lacZ cassette downstream of the melanopsin (Opn4) start codon. (J:167871, J:174940)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Opn4 (mouse) Summary of all recombinase alleles driven by Opn4. Alliance mouse Opn4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 33 strains or lines available

References

• Original: J:174940 Chen SK, et al., Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature. 2011 Aug 4;476(7358):92-5
• All: 8 reference(s)