About   Help   FAQ
Lgr5tm2.1Cle
Targeted Allele Detail
Nomenclature
Symbol: Lgr5tm2.1Cle
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 2.1, Hans Clevers
MGI ID: MGI:5285688
Synonyms: Lgr5fl
Gene: Lgr5  Location: Chr10:115450311-115587780 bp, - strand  Genetic Position: Chr10, 63.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174842
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 16. A floxed neo cassette was inserted downstream of exon 16. Cre-mediated recombination removed the neo cassette and left exon 16 floxed. (J:174842)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr5 Mutation:  3 strains or lines available
References
Original:  J:174842 de Lau W, et al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Aug 18;476(7360):293-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory