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Mettm1Ics
Targeted Allele Detail
Nomenclature
Symbol: Mettm1Ics
Name: met proto-oncogene; targeted mutation 1, Mouse Clinical Institute
MGI ID: MGI:5285647
Synonyms: MetLacZ
Gene: Met  Location: Chr6:17463800-17573980 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174591
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Duplication, Insertion
  Mettm1Ics involves 1 genes/genome features (Met) View all
 
Mutation detailsA cassette containing a loxP site, duplicated exon 12, and a neo cassette with 3 polyadenylation sequences and a 3' loxP site was inserted upstream of exon 12. An IRES, nuclear localization sequence, and lacZ gene with a polyadenlylation sequence were inserted downstream of exon 12. (J:174591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:  4 strains or lines available
Notes
ES cell line = P1 from Institut Clinique de la Souris.
References
Original:  J:174591 Lamballe F, et al., Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci. 2011 Aug 3;31(31):11144-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory