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Tg(BEST1-HTRA1)#Ybf
Transgene Detail
Nomenclature
Symbol: Tg(BEST1-HTRA1)#Ybf
Name: transgene insertion, Yingbin Fu
MGI ID: MGI:5285549
Synonyms: hHTRA1+
Transgene: Tg(BEST1-HTRA1)#Ybf  Location: unknown  
Tg(BEST1-HTRA1)#Ybf/0 mice develop polypoidal choroidal vasculopathy

Show the 6 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(BEST1-HTRA1)#Ybf expresses 1 gene
 
Mutation detailsA 1.5-kb human HTRA1 cDNA was placed under the control of the human VMD2 promoter(585 to +38 bp) and CMV enhancer/promoter. (J:175227, J:201036)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Polypoidal Choroidal Vasculopathy J:175227
References
Original:  J:175227 Jones A, et al., Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14578-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/12/2020
MGI 6.15
The Jackson Laboratory