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Targeted Allele Detail
Symbol: Mirc5tm1Jae
Name: microRNA cluster 5, including Mir290a through Mir295; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:5285428
Synonyms: mir-290-295-, xmiR290 cluster -
Gene: Mirc5  Location: unknown  Genetic Position: Chr7, Syntenic
Reduction of germ cells in testes and ovary atrophy in Mirc5tm1Jae/Mirc5tm1Jae mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:175228
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
Mutation detailsThe entire 2 kb cluster including Mir290, Mir291a, Mir292, Mir291b, Mir293, Mir294, and Mir295 was replaced with a pgk-neo cassette via homologous recombination. RT-PCR confirmed the absence of mature micro RNAs in homozygous ES cells. (J:175228)
Targeting strategy for generation of the Mirc5tm1Jae allele
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 55 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc5 Mutation:  2 strains or lines available
Original:  J:175228 Medeiros LA, et al., Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14163-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory