Bsnd^tm1Suc
Targeted Allele Detail

Summary

• Symbol: Bsnd^tm1Suc
• Name: barttin CLCNK type accessory beta subunit; targeted mutation 1, Shinichi Uchida
• MGI ID: MGI:5285212
• Synonyms: Bsnd^Neo(R8L)
• Gene: Bsnd Location: Chr4:106340653-106349440 bp, - strand Genetic Position: Chr4, 49.67 cM
• Alliance: Bsnd^tm1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175265
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with a modified exon 1 in which nucleotide substitution(s) results in the amino acid substitution of leucine for argininge at position 8 (R8L). A floxed neo cassette inserted downstream of the modified exon 1. This is a hypomorphic allele. Reduced protein expression was confirmed by western blot analysis. (J:175265)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bsnd Mutation: 16 strains or lines available

References

• Original: J:175265 Nomura N, et al., Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol. 2011 Aug;301(2):F297-307
• All: 3 reference(s)