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Bsndtm1.1Suc
Targeted Allele Detail
Nomenclature
Symbol: Bsndtm1.1Suc
Name: barttin CLCNK type accessory beta subunit; targeted mutation 1.1, Shinichi Uchida
MGI ID: MGI:5285211
Synonyms: BsndR8L
Gene: Bsnd  Location: Chr4:106483456-106492243 bp, - strand  Genetic Position: Chr4, 49.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175265
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsCre-mediated recombination removed the neo cassette downstream of the modified exon 1 with the R8L substitution (mimicking a mutation found in some Bartter syndrome patients) and removed by cre-mediated recombination. (J:175265)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bsnd Mutation:  11 strains or lines available
References
Original:  J:175265 Nomura N, et al., Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol. 2011 Aug;301(2):F297-307
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory