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Tg(Thy1-HSPB1*P182L)#Lvdb
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-HSPB1*P182L)#Lvdb
Name: transgene insertion, Ludo Van Den Bosch
MGI ID: MGI:5285201
Synonyms: HSPB1P182L, S135F
Transgene: Tg(Thy1-HSPB1*P182L)#Lvdb  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-HSPB1*P182L)#Lvdb expresses 1 gene
 
Mutation detailsThe transgene construct contains the human HSPB1 cDNA harboring the P182L mutation coupled to an N-terminal hemagglutinin (HA) tag driven by the murine Thy1.2 expression cassette. The transgene is expressed in the gray matter and in extended processes in the white matter. A # is used to indicate that a line number was not provided in the original publication. (J:174508)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:174508 d'Ydewalle C, et al., HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nat Med. 2011;17(8):968-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory