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Pdlim5tm1.1Chen
Targeted Allele Detail
Nomenclature
Symbol: Pdlim5tm1.1Chen
Name: PDZ and LIM domain 5; targeted mutation 1.1, Ju Chen
MGI ID: MGI:5284898
Synonyms: ENH-
Gene: Pdlim5  Location: Chr3:142239590-142395696 bp, - strand  Genetic Position: Chr3, 66.69 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175042
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted flanking exon 3 and an FRT flanked neomycin selection cassette was inserted downstream of exon 3. Correctly targeted mice were crossed to Tg(Prm-cre)#Og mice to excise exon 3. Western blot analysis of heart extracts demonstrated the absence of protein product. (J:175042)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdlim5 Mutation:  23 strains or lines available
References
Original:  J:175042 Cheng H, et al., Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res. 2010 Aug 6;107(3):348-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory