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Fcmrtm1.2Khl
Targeted Allele Detail
Nomenclature
Symbol: Fcmrtm1.2Khl
Name: Fc fragment of IgM receptor; targeted mutation 1.2, Kyeong-Hee Lee
MGI ID: MGI:5142529
Synonyms: Tosoko
Gene: Fcmr  Location: Chr1:130865669-130880791 bp, + strand  Genetic Position: Chr1, 56.89 cM, cytoband E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174871
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 4 through 7. Flow cytrometry confirmed the absence of protein expression. (J:174871)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcmr Mutation:  12 strains or lines available
References
Original:  J:174871 Nguyen XH, et al., Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood. 2011 Jul 21;118(3):598-608
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory