L1cam^tm1(KOMP)Mbp
Targeted Allele Detail

Summary

• Symbol: L1cam^tm1(KOMP)Mbp
• Name: L1 cell adhesion molecule; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:5141786
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• IMPC: L1cam gene page

Mutation origin

• Mutant Cell Lines: DEPD00564_1_B01, DEPD00564_1_C01, DEPD00564_1_C02, DEPD00564_1_F01, DEPD00564_1_H01, DEPD00564_1_H02, DEPD00578_2_A02, DEPD00578_2_A03, DEPD00578_2_A04, DEPD00578_2_B03, DEPD00578_2_B04, DEPD00578_2_C01, DEPD00578_2_C02, DEPD00578_2_C03, DEPD00578_2_C04, DEPD00578_2_D02, DEPD00578_2_D04, DEPD00578_2_E02, DEPD00578_2_E03, DEPD00578_2_E04, DEPD00578_2_F01, DEPD00578_2_F03, DEPD00578_2_F04, DEPD00578_2_G01, DEPD00578_2_G02, DEPD00578_2_G03, DEPD00578_2_G04, DEPD00578_2_H01, DEPD00578_2_H02, DEPD00578_2_H03, DEPD00578_2_H04
• Germline Transmission: Unknown
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3934 starting at position 72906731 and ending at position 72910665 of Chromosome X (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any L1cam Mutation: 12 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 1 reference(s)