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Cav1tm1.1Aia
Targeted Allele Detail
Nomenclature
Symbol: Cav1tm1.1Aia
Name: caveolin 1, caveolae protein; targeted mutation 1.1, Alexander I Agoulnik
MGI ID: MGI:5141474
Gene: Cav1  Location: Chr6:17306335-17341452 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174719
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the uterus. (J:174719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:  16 strains or lines available
References
Original:  J:174719 Li Z, et al., Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2. Endocrinology. 2011 Jun;152(6):2474-82
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory