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Dab1tm1.1Mull
Targeted Allele Detail
Nomenclature
Symbol: Dab1tm1.1Mull
Name: disabled 1; targeted mutation 1.1, Ulrich Mueller
MGI ID: MGI:5141401
Synonyms: Dab1flox
Gene: Dab1  Location: Chr4:103619546-104744844 bp, + strand  Genetic Position: Chr4, 47.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174747
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:174747)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dab1 Mutation:  9 strains or lines available
References
Original:  J:174747 Franco SJ, et al., Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron. 2011 Feb 10;69(3):482-97
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory