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Targeted Allele Detail
Symbol: Klf5tm1.1Jwel
Name: Kruppel-like factor 5; targeted mutation 1.1, James Wells
MGI ID: MGI:5141245
Synonyms: KD, Klf5del
Gene: Klf5  Location: Chr14:99298691-99313405 bp, + strand  Genetic Position: Chr14, 49.43 cM, cytoband E2.1
Germline Transmission:  Earliest citation of germline transmission: J:168150
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP flanked Hprt selection cassette upstream of exon1 and an additional loxP site downstream of exon 2 are inserted by homologous recombination. Transient Cre expression deleted exons 1 and 2. Although the cre-mediated deletion is predicted to result in the production of an in-frame transcript, the gene product from this allele is predicted to be non functional. Loss of protein was confirmed by immunostaining in early embryos. (J:168150)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf5 Mutation:  23 strains or lines available
Original:  J:168150 Lin SC, et al., Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010 Dec;137(23):3953-63
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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