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Tet2tm1.1Iaai
Targeted Allele Detail
Nomenclature
Symbol: Tet2tm1.1Iaai
Name: tet methylcytosine dioxygenase 2; targeted mutation 1.1, Iannis Aifantis
MGI ID: MGI:5141120
Synonyms: Tet2f
Gene: Tet2  Location: Chr3:133463677-133545136 bp, - strand  Genetic Position: Chr3, 61.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174053
Parent Cell Line:  BAC-BA1 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S/SvEv)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT- and loxP-flanked neo cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:174053)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tet2 Mutation:  744 strains or lines available
References
Original:  J:174053 Moran-Crusio K, et al., Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011 Jul 12;20(1):11-24
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory