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Targeted Allele Detail
Symbol: Unc93b1tm1.1Kmiy
Name: unc-93 homolog B1 (C. elegans); targeted mutation 1.1, Kensuke Miyake
MGI ID: MGI:5140947
Synonyms: Unc93b1D34A
Gene: Unc93b1  Location: Chr19:3935186-3949340 bp, + strand  Genetic Position: Chr19, 3.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:174308
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
Mutation detailsExon 2 was replaced with one in which an A to C mutation results in the amino acid substitution of alanine for aspartic acid at position 34 (D34A). A floxed neo cassette inserted downstream of exon 3 was removed by cre-mediated recombination. (J:174308)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Unc93b1 Mutation:  15 strains or lines available
ES cell line = EB3, derived from E14TG2a. EB3 cells carry one allele of Pou5f1 that has been inactivated via targeted integration of E14TG2a ES cells with an IRESBSDpA selection cassette. J:174308 does not mention whether the null allele of Pou5f1 is also present in the line of mice created.

Original:  J:174308 Fukui R, et al., Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking. Immunity. 2011 Jul 22;35(1):69-81
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory