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Targeted Allele Detail
Symbol: Unc93b1tm1.1Kmiy
Name: unc-93 homolog B1 (C. elegans); targeted mutation 1.1, Kensuke Miyake
MGI ID: MGI:5140947
Synonyms: Unc93b1D34A
Gene: Unc93b1  Location: Chr19:3935186-3949340 bp, + strand  Genetic Position: Chr19, 3.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:174308
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
Mutation detailsExon 2 was replaced with one in which an A to C mutation results in the amino acid substitution of alanine for aspartic acid at position 34 (D34A). A floxed neo cassette inserted downstream of exon 3 was removed by cre-mediated recombination. (J:174308)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Unc93b1 Mutation:  8 strains or lines available
ES cell line EB3, derived from E14TG2a, carries one allele of Pou5f1 that has been inactivated via targeted integration of E14TG2a ES cells with an IRESBSDpA selection cassette. J:174308 does not mention whether the null allele of Pou5f1 is also present in the line of mice created.

Original:  J:174308 Fukui R, et al., Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking. Immunity. 2011 Jul 22;35(1):69-81
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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