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Snrpntm2.1Kaj
Targeted Allele Detail
Nomenclature
Symbol: Snrpntm2.1Kaj
Name: small nuclear ribonucleoprotein N; targeted mutation 2.1, Karen A Johnstone
MGI ID: MGI:5140864
Synonyms: PWS-ICflox6kb
Gene: Snrpn  Location: Chr7:59632243-59789967 bp, - strand  Genetic Position: Chr7, 34.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174457
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted 3.7 kb upstream of exon 1. A floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination first removed the neo cassette and left the 6 kb encompassing the Prader-Willi syndrome imprinting center (PWS-IC) floxed. (J:174457)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Snrpn Mutation:  16 strains or lines available
References
Original:  J:174457 Dubose AJ, et al., A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center. Hum Mol Genet. 2011 Sep 1;20(17):3461-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory