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Targeted Allele Detail
Symbol: Ttc8tm1Reed
Name: tetratricopeptide repeat domain 8; targeted mutation 1, Randall R Reed
MGI ID: MGI:5140723
Gene: Ttc8  Location: Chr12:98920574-98983238 bp, + strand  Genetic Position: Chr12, 49.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:173465
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 15.8 kb fragment including the start codon and first 2 exons was replaced with a tau/YFP fusion construct and a floxed neo cassette via homologous recombination. In situ and immunofluorescence analysis confirmed the absence of detectable RNA and protein expression in homozygous mice. Robust reporter expression is seen in sites of endogenous gene expression (microtubules, axon bundles and the nerve and glomerular layers of the olfactory bulb). (J:173465)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttc8 Mutation:  3 strains or lines available
Original:  J:173465 Tadenev AL, et al., Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10320-5
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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