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Targeted Allele Detail
Symbol: Ttc8tm1Reed
Name: tetratricopeptide repeat domain 8; targeted mutation 1, Randall R Reed
MGI ID: MGI:5140723
Synonyms: Bbs8-
Gene: Ttc8  Location: Chr12:98920574-98983238 bp, + strand  Genetic Position: Chr12, 49.88 cM
Structural and protein localization defects in Ttc8tm1Reed/Ttc8tm1Reed olfactory epithelium

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:173465
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 15.8 kb fragment including the start codon and first 2 exons was replaced with a tau/YFP fusion construct and a floxed neo cassette via homologous recombination. In situ and immunofluorescence analysis confirmed the absence of detectable RNA and protein expression in homozygous mice. Robust reporter expression is seen in sites of endogenous gene expression (microtubules, axon bundles and the nerve and glomerular layers of the olfactory bulb). (J:173465)
Generation of the Ttc8tm1Reed allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttc8 Mutation:  0 strains or lines available
Original:  J:173465 Tadenev AL, et al., Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10320-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory