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Epb41l3tm1.1Bhat
Targeted Allele Detail
Nomenclature
Symbol: Epb41l3tm1.1Bhat
Name: erythrocyte membrane protein band 4.1 like 3; targeted mutation 1.1, Manzoor A Bhat
MGI ID: MGI:5140704
Gene: Epb41l3  Location: Chr17:69156810-69289985 bp, + strand  Genetic Position: Chr17, 40.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173383
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT flanked neo cassette and a loxP site were inserted in intron 5. A second loxP site was inserted in intron 6. Exon 6 which encodes part of theFERM domain is thus flanked by loxP sites. Deletion of exon 6 by cre mediated excision also results in a frame shift creating a stop codon in exon 7. Both 145 and 125 kDa protein isoforms were lost as determined by immunoblotting. (J:173383)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epb41l3 Mutation:  4 strains or lines available
References
Original:  J:173383 Buttermore ED, et al., The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J Neurosci. 2011 Jun 1;31(22):8013-8024
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory