Jam3^tm1.2Chav
Targeted Allele Detail

Summary

• Symbol: Jam3^tm1.2Chav
• Name: junction adhesion molecule 3; targeted mutation 1.2, Triantafyllos Chavakis
• MGI ID: MGI:5140161
• Gene: Jam3 Location: Chr9:27008680-27066717 bp, - strand Genetic Position: Chr9, 12.27 cM
• Alliance: Jam3^tm1.2Chav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173391
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 760 bp gene fragment including 560 bp of promoter region and exon 1 was flanked by loxP sites. An FRT flanked PGK-neo cassette was inserted as well. Mice were crossed with an unspecified flp-deleter mouse to excise the selection cassette. Exon 1 including the translationaql start codon and the promoter region were excised by crossing to Tg(EIIa-cre)C5379Lmgd mice. (J:173391)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jam3 Mutation: 24 strains or lines available

References

• Original: J:173391 Langer HF, et al., A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis. Cancer Res. 2011 Jun 15;71(12):4096-4105
• All: 1 reference(s)