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Targeted Allele Detail
Symbol: Jam3tm1.2Chav
Name: junction adhesion molecule 3; targeted mutation 1.2, Triantafyllos Chavakis
MGI ID: MGI:5140161
Gene: Jam3  Location: Chr9:27097384-27155421 bp, - strand  Genetic Position: Chr9, 12.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:173391
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 760 bp gene fragment including 560 bp of promoter region and exon 1 was flanked by loxP sites. An FRT flanked PGK-neo cassette was inserted as well. Mice were crossed with an unspecified flp-deleter mouse to excise the selection cassette. Exon 1 including the translationaql start codon and the promoter region were excised by crossing to Tg(EIIa-cre)C5379Lmgd mice. (J:173391)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jam3 Mutation:  3 strains or lines available
Original:  J:173391 Langer HF, et al., A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis. Cancer Res. 2011 Jun 15;71(12):4096-4105
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory