Cygb^tm1Nka
Targeted Allele Detail

Summary

• Symbol: Cygb^tm1Nka
• Name: cytoglobin; targeted mutation 1, Norifumi Kawada
• MGI ID: MGI:5140136
• Gene: Cygb Location: Chr11:116536421-116544887 bp, - strand Genetic Position: Chr11, 81.45 cM, cytoband E2
• Alliance: Cygb^tm1Nka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174134
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 including the translation initiation site was replaced with a floxed pgk-neo cassette via homologous recombination. RT-PCR, immunoblot, and immunohistochemical analysis confirmed the absence of expression in livers from homozygous mice. (J:174134)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cygb^tm1Nka

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cygb Mutation: 17 strains or lines available

References

• Original: J:174134 Thi Thanh Thuy L, et al., Promotion of Liver and Lung Tumorigenesis in DEN-Treated Cytoglobin-Deficient Mice. Am J Pathol. 2011 Aug;179(2):1050-60
• All: 8 reference(s)