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Trp53tm4Att
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm4Att
Name: transformation related protein 53; targeted mutation 4, Laura D Attardi
MGI ID: MGI:5140078
Synonyms: p53LSL-25,26,53,54
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173395
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed puromycin/transcription stop cassette was inserted upstream of exon 2. In addition,mutations were inserted in exon 2 altering the codons for amino acid 25 from leucine to glutamine and amino acid 26 from tryptophan to serine. Further changes in exon 4 altered codon 53 from phenylalanine to glutamine and codon 54 from phenylalanine to serine. Both transactivation domains are incapacitated once the stop sequences are removed by cre expression. (J:173395)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  205 strains or lines available
References
Original:  J:173395 Brady CA, et al., Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell. 2011 May 13;145(4):571-83
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory