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Targeted Allele Detail
Symbol: Pou2f3tm1Abek
Name: POU domain, class 2, transcription factor 3; targeted mutation 1, Keiko Abe
MGI ID: MGI:5140071
Synonyms: Skn-1a-
Gene: Pou2f3  Location: Chr9:43123927-43205755 bp, - strand  Genetic Position: Chr9, 24.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:173905
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn approximately 4 kb fragment, including exons 7 - 9 encoding for the POU homeodomain and a part of the POU?specific domain, was replaced with a tk-neo cassette via homologous recombination. In situ and immunohistochemical analysis indicated the expression of a truncated mRNA in a small population of basal cells and the absence of the a isoform of the protein in the taste buds of homozygous mice. (J:173905)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pou2f3 Mutation:  21 strains or lines available
Original:  J:173905 Matsumoto I, et al., Skn-1a (Pou2f3) specifies taste receptor cell lineage. Nat Neurosci. 2011 Jun;14(6):685-7
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory