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Tg(Thy1-GLRA1*R271Q)300Wha
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-GLRA1*R271Q)300Wha
Name: transgene insertion 300, Hans Weiher
MGI ID: MGI:5086230
Synonyms: Tg271Q, tg271Q-300, Tg(Thy1-Glra1*R271Q)300Wha
Transgene: Tg(Thy1-GLRA1*R271Q)300Wha  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 X DBA/2)F1 x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
This is the highest expressing of four transgenic mouse lines derived from founder mice bearing this transgene construct, which the authors designate tg271Q-300, tg271Q-331, tg271Q354 and tg271Q-382 ( J:76009).

Phenotypic Similarity to Human Syndrome: REM Sleep Behavior Disorder

References
Original:  J:76009 Becker L, et al., Disease-specific human glycine receptor alpha1 subunit causes hyperekplexia phenotype and impaired glycine- and GABA(A)-receptor transmission in transgenic mice. J Neurosci. 2002 Apr 1;22(7):2505-12
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory