Homer1^tm2Mhd
Targeted Allele Detail

Summary

• Symbol: Homer1^tm2Mhd
• Name: homer scaffolding protein 1; targeted mutation 2, Marlin H Dehoff
• MGI ID: MGI:5086112
• Synonyms: H1a^-, Homer1a^-
• Gene: Homer1 Location: Chr13:93436143-93541637 bp, + strand Genetic Position: Chr13, 47.83 cM
• Alliance: Homer1^tm2Mhd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174500
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A rat cDNA containing exons 6 through 10, which encodes the 'c' isoform, followed by a floxed neo cassette was inserted in frame with exon 5 and replaced alternative exons for the immediate-early isoforms 'a' and 'Ania3'. The absence of the 'a' isoform was confirmed by western blot analysis following induction of expression by maximal electroconvulsive seizure. Expression of the 'b' and 'c' isoform is normal. (J:174500)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Homer1 Mutation: 24 strains or lines available

References

• Original: J:174500 Hu JH, et al., Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron. 2010 Dec 22;68(6):1128-42
• All: 8 reference(s)