About   Help   FAQ
Ccm2tm2.1Sbn
Targeted Allele Detail
Nomenclature
Symbol: Ccm2tm2.1Sbn
Name: cerebral cavernous malformation 2; targeted mutation 2.1, Ulrich Siebenlist
MGI ID: MGI:5085315
Synonyms: Ccm2flox
Gene: Ccm2  Location: Chr11:6546887-6596744 bp, + strand  Genetic Position: Chr11, 4.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174085
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:174085)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccm2 Mutation:  39 strains or lines available
References
Original:  J:174085 Cunningham K, et al., Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet. 2011 Aug 15;20(16):3198-206
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/01/2019
MGI 6.14
The Jackson Laboratory