Smad2tm1.1Nomu
Targeted Allele Detail
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Symbol: |
Smad2tm1.1Nomu |
Name: |
SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura |
MGI ID: |
MGI:5085284 |
Synonyms: |
Smad2flox |
Gene: |
Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
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Alliance: |
Smad2tm1.1Nomu page
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Cerebellar ataxia in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 mice
Show the 6 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:173787
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 8. Cre-mediated recombination removed the neo cassette and left exons 7 and 8 floxed.
(J:173787)
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Generation of the floxed Smad2tm1.1Nomu allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Smad2 Mutation: |
50 strains or lines available
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Original: |
J:173787 Wang L, et al., Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice. J Biol Chem. 2011 May 27;286(21):18766-74 |
All: |
9 reference(s) |
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