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Targeted Allele Detail
Symbol: Smad2tm1.1Nomu
Name: SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura
MGI ID: MGI:5085284
Synonyms: Smad2flox
Gene: Smad2  Location: Chr18:76241580-76310963 bp, + strand  Genetic Position: Chr18, 51.42 cM
Cerebellar ataxia in Smad2tm1.1Nomu/Smad2tm1.1Nomu Tg(Nes-cre)1Kln/0 mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:173787
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 8. Cre-mediated recombination removed the neo cassette and left exons 7 and 8 floxed. (J:173787)
Generation of the floxed Smad2tm1.1Nomu allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  18 strains or lines available
Original:  J:173787 Wang L, et al., Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice. J Biol Chem. 2011 May 27;286(21):18766-74
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory