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Aurkbtm1.2Mama
Targeted Allele Detail
Nomenclature
Symbol: Aurkbtm1.2Mama
Name: aurora kinase B; targeted mutation 1.2, Marcos Malumbres
MGI ID: MGI:5056428
Synonyms: Aurkb(-)
Gene: Aurkb  Location: Chr11:69045647-69051664 bp, + strand  Genetic Position: Chr11, 42.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173575
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 2 - 6. (J:173575)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aurkb Mutation:  9 strains or lines available
References
Original:  J:173575 Fernandez-Miranda G, et al., Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development. 2011 Jul;138(13):2661-72
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory