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Tubb2bbrdp
Chemically induced Allele Detail
Nomenclature
Symbol: Tubb2bbrdp
Name: tubulin, beta 2B class IIB; brain dimple
MGI ID: MGI:5056364
Gene: Tubb2b  Location: Chr13:34127008-34130354 bp, - strand  Genetic Position: Chr13, 14.04 cM, cytoband A4
Mutation
origin
Strain of Origin:  A/J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is an A to G substitution at coding nucleotide 740 in exon 4 of the cDNA (c.740A>G, NM_023716). This changes the asparagine residue to serine at position 247 of the encoded protein (N247S). (J:201099)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tubb2b Mutation:  4 strains or lines available
References
Original:  J:174027 Stottmann RW, et al., Focusing Forward Genetics: A Tripartite ENU Screen for Neurodevelopmental Mutations in the Mouse. Genetics. 2011 Jul;188(3):615-24
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory