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Tg(JPH3*)CXwy
Transgene Detail
Nomenclature
Symbol: Tg(JPH3*)CXwy
Name: transgene insertion C, X William Yang
MGI ID: MGI:5052363
Synonyms: BAC-HDL2
Transgene: Tg(JPH3*)CXwy  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(JPH3*)CXwy expresses 1 gene
 
Mutation detailsThe human BAC (RP11-33A21) was modified to include an expanded CTG/CAG track of 120 repeats in exon 2A of JPH3. This line has a single integration of the transgene with 116 CTG/CAG repeats. RT-PCR analysis indicates the level of overexpression of the transgene was about 100% of the endogenous gene. (J:174267)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:174267 Wilburn B, et al., An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice. Neuron. 2011 May 12;70(3):427-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory