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Pdcd10tm1Kwhi
Targeted Allele Detail
Nomenclature
Symbol: Pdcd10tm1Kwhi
Name: programmed cell death 10; targeted mutation 1, Kevin Whitehead
MGI ID: MGI:5052183
Synonyms: Pdcd10flox
Gene: Pdcd10  Location: Chr3:75516490-75556852 bp, - strand  Genetic Position: Chr3, 33.76 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173947
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsOne loxP site was inserted in intron 3 just 5' to exon 4. A neomycin resistance cassette, a second loxP site and an EGFP construct were inserted 3' to exon 8. Cre mediated excision will remove exons 4-8 and the resistance cassette. This results in a fusion protein composed of exons 1-3 and EGFP. (J:173947)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcd10 Mutation:  7 strains or lines available
References
Original:  J:173947 Chan AC, et al., Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest. 2011 May 2;121(5):1871-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory