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Gt(ROSA)26Sortm1(Actb-Met)Fmai
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Actb-Met)Fmai
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Flavio Maina
MGI ID: MGI:5052130
Synonyms: Gt(ROSA)26Sortm1(Actb-Met)Pali, Mettg, Rosa26LacZ-stop-Met
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173661
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Actb-Met)Fmai expresses 1 gene
 
Mutation detailsThe targeting construct was compased of a Met gene located downstream of a CMV enhancer beta actin promoter and a floxed stop cassette. Met expression requires cre excision of the stop cassette. (J:173661, J:220592)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  497 strains or lines available
References
Original:  J:173661 Tonges L, et al., Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J Neurochem. 2011 Jun;117(5):892-903
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory