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Tg(Eno2-PSEN2*)1480Ykk
Transgene Detail
Nomenclature
Symbol: Tg(Eno2-PSEN2*)1480Ykk
Name: transgene insertion 1480, Yong K Kim
MGI ID: MGI:5052118
Synonyms: NSE-hPS2m
Transgene: Tg(Eno2-PSEN2*)1480Ykk  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Eno2-PSEN2*)1480Ykk expresses 1 gene
 
Mutation detailsA 1.8kb fragment of the rat Eno2 promoter drives expression of a human PSEN2 cDNA with an N141I mutation found in Volga German families. The highest levels of transgene mRNA expression were detected in the anterior brain, followed by posterior brain, muscle, lung, heart, and liver. (J:76934)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:76934 Hwang DY, et al., Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. FASEB J. 2002 Jun;16(8):805-13
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory