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Tg(Mapt-MAPT*)#Hanr
Transgene Detail
Summary
Symbol: Tg(Mapt-MAPT*)#Hanr
Name: transgene insertion, Hanna Rosenmann
MGI ID: MGI:5052111
Synonyms: DM-htau
Transgene: Tg(Mapt-MAPT*)#Hanr  Location: unknown  
Alliance: Tg(Mapt-MAPT*)#Hanr page
Transgene
origin
Strain of Origin:  C57BL/6 x BALB/c
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Mapt-MAPT*)#Hanr expresses 1 gene
 
Mutation detailsA fragment of the rat Mapt promoter drives expression of a human MAPT cDNA coding for the short four repeat isoform, containing 2 pathogenic mutations, K257T and P301S. Expression of the mutant MAPT protein is about 5-10% that of the endogenous protein. (J:137947)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: tauopathy (J:137947)
References
Original:  J:137947 Rosenmann H, et al., A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol. 2008 Jul;212(1):71-84
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory