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Tg(Mapt-MAPT*)#Hanr
Transgene Detail
Nomenclature
Symbol: Tg(Mapt-MAPT*)#Hanr
Name: transgene insertion, Hanna Rosenmann
MGI ID: MGI:5052111
Synonyms: DM-htau
Transgene: Tg(Mapt-MAPT*)#Hanr  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x BALB/c
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Mapt-MAPT*)#Hanr expresses 1 gene
 
Mutation detailsA fragment of the rat Mapt promoter drives expression of a human MAPT cDNA coding for the short four repeat isoform, containing 2 pathogenic mutations, K257T and P301S. Expression of the mutant MAPT protein is about 5-10% that of the endogenous protein. (J:137947)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: tauopathy (J:137947)

References
Original:  J:137947 Rosenmann H, et al., A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol. 2008 Jul;212(1):71-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory