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Ptgdstm1.1(cre)Gvn
Targeted Allele Detail
Nomenclature
Symbol: Ptgdstm1.1(cre)Gvn
Name: prostaglandin D2 synthase (brain); targeted mutation 1.1, Marco Giovannini
MGI ID: MGI:5051626
Synonyms: PGDSCre
Gene: Ptgds  Location: Chr2:25466709-25470046 bp, - strand  Genetic Position: Chr2, 17.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173718
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was constructed with the nls-cre recombinase sequence fused to exon 1 of the Ptgds locus and a poly A signal with a floxed EGFP-hygromycin selection cassette 3' to the cre poly A signal. Homologous recombination in ES cells was performed to replace exon 1 with the targeting construct. Chimeras were crossed with FVB/N mice. The floxed selection cassette was excised by crossing offspring to the Tg(EIIa-cre)C5379Lmgd deletor line and the EIIa transgene was bred from the background. (J:173718)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ptgds     Summary of all recombinase alleles driven by Ptgds.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgds Mutation:  9 strains or lines available
References
Original:  J:173718 Kalamarides M, et al., Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes. Oncogene. 2011 May 19;30(20):2333-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory