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Targeted Allele Detail
Symbol: Ptgdstm1.1(cre)Gvn
Name: prostaglandin D2 synthase (brain); targeted mutation 1.1, Marco Giovannini
MGI ID: MGI:5051626
Synonyms: PGDSCre
Gene: Ptgds  Location: Chr2:25356721-25360058 bp, - strand  Genetic Position: Chr2, 17.28 cM
Germline Transmission:  Earliest citation of germline transmission: J:173718
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was constructed with the nls-cre recombinase sequence fused to exon 1 of the Ptgds locus and a poly A signal with a floxed EGFP-hygromycin selection cassette 3' to the cre poly A signal. Homologous recombination in ES cells was performed to replace exon 1 with the targeting construct. Chimeras were crossed with FVB/N mice. The floxed selection cassette was excised by crossing offspring to the Tg(EIIa-cre)C5379Lmgd deletor line and the EIIa transgene was bred from the background. (J:173718)
 Tissue activity of this recombinase allele
Driver: Ptgds (mouse) Summary of all recombinase alleles driven by Ptgds.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgds Mutation:  11 strains or lines available
Original:  J:173718 Kalamarides M, et al., Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes. Oncogene. 2011 May 19;30(20):2333-44
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory