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Mitftm7Arnh
Targeted Allele Detail
Nomenclature
Symbol: Mitftm7Arnh
Name: microphthalmia-associated transcription factor; targeted mutation 7, Heinz Arnheiter
MGI ID: MGI:5050706
Synonyms: Mitfmi-S73ANeo
Gene: Mitf  Location: Chr6:97807058-98021349 bp, + strand  Genetic Position: Chr6, 45.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182722
Parent Cell Line:  LC3 (ES Cell)
Strain of Origin:  (C57BL/6N x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe targeted mutation was within exon 2B to change the coding sequence for amino acid 73 from serine to alanine (S73A) and a silent nucleotide change 10bp upstream to generate a diagnostic restriction site. A floxed neomycin selection cassette was also inserted into intron 2. (J:182722)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mitf Mutation:  44 strains or lines available
References
Original:  J:182722 Debbache J, et al., In vivo Role of Alternative Splicing and Serine Phosphorylation of the Microphthalmia-associated Transcription Factor MITF. Genetics. 2012 Feb 23;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory