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Targeted Allele Detail
Symbol: Msx1tm2.1(cre/ERT2)Bero
Name: msh homeobox 1; targeted mutation 2.1, Benoit Robert
MGI ID: MGI:5049923
Synonyms: Msx1CreERT2, Msx1tm2(cre/ERT2)Bero
Gene: Msx1  Location: Chr5:37820485-37824583 bp, - strand  Genetic Position: Chr5, 20.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:173525
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    induced by tamoxifen
Mutation:    Insertion
Mutation detailsA targeting vector with the cre/ERT2 sequence, polyadenylation site, and an Frt-flanked neomycin cassette inserted into the ATG site of Msx1 in a plasmid was generated by homologous recombination in bacteria. The linearized targeting vector was electroporated into ES cells and targeted clones were used to generated chimeras. F1 offspring were crossed to Flp deleter mice to delete the neo marker. (J:173525, J:194129)
 Tissue activity of this recombinase allele
Driver: Msx1     Summary of all recombinase alleles driven by Msx1.

View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msx1 Mutation:  6 strains or lines available
Original:  J:173525 Lopes M, et al., Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development. 2011 Jul;138(14):3055-66
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory