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Tg(Tph2-icre/ERT2)6Gloss
Transgene Detail
Nomenclature
Symbol: Tg(Tph2-icre/ERT2)6Gloss
Name: transgene insertion 6, Bernd Gloss
MGI ID: MGI:5049908
Synonyms: TPH2-iCreER
Transgene: Tg(Tph2-icre/ERT2)6Gloss  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6NTac
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe mouse bacterial artificial chromosome (BAC) RP23-151J17 containing Tph2, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, gene, was modified by insertion of sequence encoding iCreER at the Tph2 translation initiation ATG, and addition of a Kozak sequence upstream of the ATG. This BAC also contains the following genes: Tbc1d15, (TBC1 domain family, member 15 ), and AK048828. The modified BAC was used to generate the TPH2-iCreER transgene, which was microinjected into C57BL/6NTac fertilized eggs. Founder line 6 was subsequently established. (J:173677)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tph2     Summary of all recombinase alleles driven by Tph2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:173677 Gloss B, Generation of an inducible Tph2 cre transgene. MGI Direct Data Submission. 2011;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory