Tg(Tph2-icre/ERT2)6Gloss
Transgene Detail

Summary

• Symbol: Tg(Tph2-icre/ERT2)6Gloss
• Name: transgene insertion 6, Bernd Gloss
• MGI ID: MGI:5049908
• Synonyms: TPH2-iCreER
• Transgene: Tg(Tph2-icre/ERT2)6Gloss Location: unknown
• Alliance: Tg(Tph2-icre/ERT2)6Gloss page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tph2-icre/ERT2)6Gloss expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tph2 (MGI:2651811)

• Mutation details: The mouse bacterial artificial chromosome (BAC) RP23-151J17 containing Tph2, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, gene, was modified by insertion of sequence encoding iCreER at the Tph2 translation initiation ATG, and addition of a Kozak sequence upstream of the ATG. This BAC also contains the following genes: Tbc1d15, (TBC1 domain family, member 15 ), and AK048828. The modified BAC was used to generate the TPH2-iCreER transgene, which was microinjected into C57BL/6NTac fertilized eggs. Founder line 6 was subsequently established. (J:173677)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tph2 (mouse) Summary of all recombinase alleles driven by Tph2. Alliance mouse Tph2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:173677 Gloss B, Generation of an inducible Tph2 cre transgene. MGI Direct Data Submission. 2011
• All: 10 reference(s)